P2Y12 inhibitors: do they increase cancer risk?

Peroxisome Proliferator-Activated Receptor Agonists: Do They Increase Cardiovascular Risk?

Cardiovascular disease is a major cause of morbidity and mortality among people with type 2 diabetes mellitus. The peroxisome proliferator-activated receptor (PPAR) agonists have a significant role on glucose and fat metabolism. Thiazolidinediones (TZDs) are predominantly PPARγ agonists, and their primary benefit appears to be the prevention of diabetic complications by improving glycemic contr...

Do cyclooxygenase inhibitors increase risk of cardiovascular thrombotic events?

Universal Grammar and Chaos/Complexity Theory: Where Do They Meet And Where Do They Cross?

  Abstract The present study begins by sketching "Chaos/Complexity Theory" (C/CT) and its applica-tion to the nature of language and language acquisition. Then, the theory of "Universal Grammar" (UG) is explicated with an eye to C/CT. Firstly, it is revealed that CCT may or may not be allied with a theory of language acquisition that takes UG as the initial state of language acquisition for ...

Proton pump inhibitors: are they overutilised in clinical practice and do they pose significant risk?

Proton pump inhibitors are highly effective acid suppressants with decades of use highlighting positive outcomes in millions of patients worldwide, and they offer minimal risk of adverse events. PPIs are considered overutilised when prescribed without an appropriate indication, when patients are left on them 'indefinitely' without appropriate indications and when they are continued after being ...

Specific PKG inhibitors: do they really exist?

Background Cellular cGMP effects can be mediated by a number of effectors including cGMP-dependent protein kinases (PKGs), cGMP-stimulated phosphodiesterase (PDE2), cGMP-inhibited phosphodiesterase (PDE3), and cGMPgated channels. Pharmacological inhibitors of PKG are often used to discriminate between these diverse cGMP effects. Currently used PKG inhibitors can be divided into three classes: c...